Decreased cortisol response to insulin induced hypoglycaemia in asthmatics treated with inhaled fluticasone propionate

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Decreased cortisol response to insulin induced hypoglycaemia in asthmatics treated with inhaled fluticasone propionate.

AIMS To assess adrenal function in asthmatic children treated with inhaled fluticasone propionate for up to 16 weeks. METHODS Children with asthma and bronchial hyperresponsiveness to inhaled methacholine were treated with inhaled fluticasone 250-750 microg/day via Volumatic spacer. The insulin tolerance test (ITT) was performed to assess adrenal function. RESULTS Eighteen asthmatic patient...

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Intranasal ciclesonide coadministration with inhaled fluticasone propionate-salmeterol does not suppress cortisol in allergic rhinitis patients.

Intranasal and inhaled corticosteroid administration concurrently in comorbid allergic rhinitis (AR) and asthma may potentially enhance cortisol suppression. This study determined whether intranasal ciclesonide 200 micro g once daily has an additional effect on cortisol suppression when coadministered with inhaled fluticasone propionate-salmeterol (FP-SAL) 500 to 50 micro g twice daily. Adults ...

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Acute adrenal crisis in asthmatics treated with high-dose fluticasone propionate.

Four cases of asthma (one adult, three children) developing acute adrenal crisis after introduction of high-dose inhaled fluticasone proprionate are presented. The three children, aged 7-9 yrs, had been prescribed inhaled fluticasone, dosage 500-2,000 microg x day(-1) and duration 5 months-5 yrs. All presented with convulsions due to hypoglycaemia (blood glucose 1.3-1.8 mM). The fourth case was...

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Basal cortisol in asthmatics on two different doses of fluticasone propionate.

OBJECTIVES To evaluate basal plasma cortisol in persistent asthmatics on inhaled fluticasone propionate 200 mcg/day and 300 mcg/day. METHODS Asthma diagnosis and classification was based on Global Initiative for Asthma recommendations. Patients aged 11 years old or less received fluticasone propionate 200 mcg/day and those older than 11 years received 300 mcg/day. After 10 weeks of treatment,...

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Inhaled and intranasal fluticasone propionate and haematoma

Fluticasone propionate is a locally acting potent corticosteroid and is registered in the Netherlands since November 1990. It is marketed as nasal drops and nasal spray (Flixonase) for the indications vasomotor and allergic rhinitis, nasal polyps, and as inhalation corticosteroid (ICS) (Flixotide) in both an inhalation dosisaerosol and a powder inhalation form for indications asthma and chronic...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 2004

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.2002.020560